| Gene Information | |
|---|---|
| Gene Name | EEF1A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 462 |
| Protein Names | Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) |
| Target Name | elongation factor 1-alpha 1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000156508 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P68104 |
| Gene Card | EEF1A1 |
| Uniprot ID | P68104 |
| Pfam | PF00009; PF03144; PF03143 |
| In ASD | no |
| Allosteric Prediction | yes (1.096682894) |
| Ortholog in Animals | Pig_ EEF1A1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EEF1A2, EFTUD2, EIF2S3, EIF2S3B, GTPBP1, GUF1, EIF5B, MTIF2, EEF2, EFL1, GSPT2, EEFSEC, HBS1L, GTPBP2, GFM2, GFM1, GSPT1, TUFM |
| Tissue | NA |
| Tissue Specificity | Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.003361(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3C5J (X-ray 1.80A ) 6ZMO (EM 3.10A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19158340, ECO:0000269|PubMed:8650580}. Nucleus {ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:8650580}. Nucleus, nucleolus {ECO:0000269|PubMed:8650580}. Cell membrane {ECO:0000269|PubMed:26497934}. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery (PubMed:19158340). Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens (PubMed:8650580). Localization at the cell membrane depends on EEF1A1 phosphorylation status and the presence of PPP1R16B (PubMed:26497934). {ECO:0000269|PubMed:19158340, ECO:0000269|PubMed:26497934, ECO:0000269|PubMed:8650580}. |
| Mouse PG classification | NA |
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