| Gene Information | |
|---|---|
| Gene Name | ABCG5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 651 |
| Protein Names | ATP-binding cassette sub-family G member 5 (EC 7.6.2.-) (Sterolin-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000138075 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H222 |
| Gene Card | ABCG5 |
| Uniprot ID | Q9H222 |
| Pfam | PF01061; PF19055; PF00005 |
| In ASD | no |
| Allosteric Prediction | yes (0.617946769) |
| Ortholog in Animals | Alpaca_ ABCG5 ( ortholog_one2one ) Dog_ ABCG5 ( ortholog_one2one ) GuineaPig_ ABCG5 ( ortholog_one2one ) Macaque_ ABCG5 ( ortholog_one2one ) Mouse_ Abcg5 ( ortholog_one2one ) Pig_ ABCG5 ( ortholog_one2one ) Rat_ Abcg5 ( ortholog_one2one ) Rabbit_ ABCG5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ABCG8, ABCG4, ABCG1, ABCG2 |
| Tissue | duodenum, liver, small.intestine |
| Tissue Specificity | Strongly expressed in the liver, lower levels in the small intestine and colon. {ECO:0000269|PubMed:11099417, ECO:0000269|PubMed:11138003}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5DO7 (X-ray 3.93A ) 7JR7 (EM 3.30A ) 7R87 (EM 3.40A ) 7R88 (EM 3.50A ) 7R89 (EM 2.60A ) 7R8A (EM 2.90A ) 7R8B (EM 3.10A ) 8CUB (X-ray 4.05A ) |
| DBSNP | rs6756629 rs758551848 rs119480069 rs119479067 rs119479067 rs575266356 rs17031672 rs140899003 rs779109455 rs6720173 rs140374206 |
| Subcellular location [CC] | Cell membrane {ECO:0000305|PubMed:16893193, ECO:0000305|PubMed:27144356}; Multi-pass membrane protein {ECO:0000269|PubMed:27144356}. Apical cell membrane {ECO:0000269|PubMed:14504269}; Multi-pass membrane protein {ECO:0000269|PubMed:27144356}. |
| Mouse PG classification | HPG |
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