| Gene Information | |
|---|---|
| Gene Name | GBP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 591 |
| Protein Names | Guanylate-binding protein 2 (EC 3.6.5.-) (GTP-binding protein 2) (GBP-2) (HuGBP-2) (Guanine nucleotide-binding protein 2) (Interferon-induced guanylate-binding protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 18 ( ENSG00000162645 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P32456 |
| Gene Card | GBP2 |
| Uniprot ID | P32456 |
| Pfam | PF02263; PF02841 |
| In ASD | no |
| Allosteric Prediction | yes (0.100956887) |
| Ortholog in Animals | Alpaca_ GBP2 ( ortholog_one2one ) Mouse_ Gbp2 ( ortholog_one2many ) Mouse_ Gbp2b ( ortholog_one2many ) Rat_ Gbp2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ATL1, GBP5, ATL2, GBP7, ATL3, GBP6, GBP1, RNF112, GBP4, GBP3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6VKJ (X-ray 2.10A ) 7E58 (X-ray 2.60A ) 7M1S (X-ray 2.91A ) |
| DBSNP | rs2230336 rs1803632 rs2230338 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21151871}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21151871}. Golgi apparatus membrane {ECO:0000269|PubMed:21151871}. Membrane; Lipid-anchor {ECO:0000269|PubMed:21151871}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9Z0E6}. Note=GBP2-GBP5 dimers localize to the Golgi apparatus. {ECO:0000269|PubMed:21151871}. |
| Mouse PG classification | NA |
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