| Gene Information | |
|---|---|
| Gene Name | POGLUT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 392 |
| Protein Names | Protein O-glucosyltransferase 1 (EC 2.4.1.376) (CAP10-like 46 kDa protein) (hCLP46) (KTEL motif-containing protein 1) (Myelodysplastic syndromes relative protein) (O-glucosyltransferase Rumi homolog) (hRumi) (Protein O-xylosyltransferase POGLUT1) (EC 2.4.2.63) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000163389 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8NBL1 |
| Gene Card | POGLUT1 |
| Uniprot ID | Q8NBL1 |
| Pfam | PF05686 |
| In ASD | no |
| Allosteric Prediction | no (-0.96055107) |
| Ortholog in Animals | Alpaca_ POGLUT1 ( ortholog_one2one ) GuineaPig_ POGLUT1 ( ortholog_one2one ) Macaque_ POGLUT1 ( ortholog_one2one ) Mouse_ Poglut1 ( ortholog_one2one ) Pig_ POGLUT1 ( ortholog_one2one ) Rat_ Poglut1 ( ortholog_one2one ) Rabbit_ POGLUT1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | POGLUT2, POGLUT3 |
| Tissue | NA |
| Tissue Specificity | Expressed in most adult tissues at different intensities. Abundantly expressed in liver. Expressed also in brain, heart, skeletal muscle, spleen, kidney, placenta, lung and peripheral blood leukocyte. Not detectable in colon, thymus and small intestine. Expressed in the epidermis, especially in the upper parts, stratum spinosum and stratum granulosum (at protein level). {ECO:0000269|PubMed:16524674, ECO:0000269|PubMed:24387993}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5L0R (X-ray 1.50A ) 5L0S (X-ray 1.45A ) 5L0T (X-ray 1.43A ) 5L0U (X-ray 1.80A ) 5L0V (X-ray 1.30A ) 5UB5 (X-ray 2.09A ) |
| DBSNP | rs11556605 rs1454300079 rs17852785 rs550944082 |
| Subcellular location [CC] | Endoplasmic reticulum lumen {ECO:0000269|PubMed:16524674, ECO:0000269|PubMed:24387993, ECO:0000269|PubMed:27807076}. |
| Mouse PG classification | NA |
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