| Gene Information | |
|---|---|
| Gene Name | EDN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 178 |
| Protein Names | Endothelin-2 (ET-2) (Preproendothelin-2) (PPET2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000127129 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P20800 |
| Gene Card | EDN2 |
| Uniprot ID | P20800 |
| Pfam | PF00322 |
| In ASD | no |
| Allosteric Prediction | yes (0.057144642) |
| Ortholog in Animals | Alpaca_ EDN2 ( ortholog_one2one ) Dog_ EDN2 ( ortholog_one2one ) GuineaPig_ EDN2 ( ortholog_one2one ) Macaque_ EDN2 ( ortholog_one2one ) Mouse_ Edn2 ( ortholog_one2one ) Pig_ EDN2 ( ortholog_one2one ) Rat_ Edn2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EDN1, EDN3 |
| Tissue | esophagus, small.intestine |
| Tissue Specificity | Expressed in lung, but not in placental stem villi vessels or cultured placental villi smooth muscle cells. {ECO:0000269|PubMed:9284755}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs5798 rs11572371 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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