| Gene Information | |
|---|---|
| Gene Name | EDN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 212 |
| Protein Names | Endothelin-1 (Preproendothelin-1) (PPET1) [Cleaved into: Endothelin-1 (ET-1); Big endothelin-1] |
| Target Name | endothelin-1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000078401 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P05305 |
| Gene Card | EDN1 |
| Uniprot ID | P05305 |
| Pfam | PF00322 |
| In ASD | no |
| Allosteric Prediction | yes (1.136333181) |
| Ortholog in Animals | Alpaca_ EDN1 ( ortholog_one2one ) Dog_ EDN1 ( ortholog_one2one ) GuineaPig_ EDN1 ( ortholog_one2one ) Macaque_ EDN1 ( ortholog_one2one ) Mouse_ Edn1 ( ortholog_one2one ) Pig_ EDN1 ( ortholog_one2one ) Rat_ Edn1 ( ortholog_one2one ) Rabbit_ EDN1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EDN3, EDN2 |
| Tissue | NA |
| Tissue Specificity | Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells. {ECO:0000269|PubMed:9284755}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.117317(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1EDN (X-ray 2.18A ) 1EDP (NMR - ) 1T7H (X-ray 1.13A ) 1V6R (NMR - ) 5GLH (X-ray 2.80A ) 6DK5 (X-ray 1.85A ) |
| DBSNP | rs587777233 rs587777232 rs587777231 rs6413478 rs5370 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |