| Gene Information | |
|---|---|
| Gene Name | EDN |
| Organism | Homo sapiens (Human) |
| Gene Length | 161 |
| Protein Names | Non-secretory ribonuclease (EC 4.6.1.18) (Eosinophil-derived neurotoxin) (RNase UpI-2) (Ribonuclease 2) (RNase 2) (Ribonuclease US) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P10153 |
| Gene Card | RNASE2 |
| Uniprot ID | P10153 |
| Pfam | PF00074 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Liver, lung, spleen, leukocytes and body fluids. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1GQV (X-ray 0.98A ) 1HI2 (X-ray 1.60A ) 1HI3 (X-ray 1.80A ) 1HI4 (X-ray 1.80A ) 1HI5 (X-ray 1.80A ) 1K2A (X-ray 1.00A ) 2BEX (X-ray 1.99A ) 2BZZ (X-ray 0.98A ) 2C01 (X-ray 1.24A ) 2C02 (X-ray 2.00A ) 2C05 (X-ray 1.86A ) 5E13 (X-ray 1.34A ) 6SSO (X-ray 1.21A ) |
| DBSNP | rs8012891 rs146887874 |
| Subcellular location [CC] | Lysosome {ECO:0000305}. Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule. |
| Mouse PG classification | NA |
| click here to return to the previous page | |