| Gene Information | |
|---|---|
| Gene Name | EDG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 382 |
| Protein Names | Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P21453 |
| Gene Card | S1PR1 |
| Uniprot ID | P21453 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3V2W (X-ray 3.35A ) 3V2Y (X-ray 2.80A ) 7EO2 (EM 2.89A ) 7EO4 (EM 2.86A ) 7EVY (EM 2.98A ) 7EVZ (EM 3.07A ) 7EW0 (EM 3.42A ) 7EW7 (EM 3.27A ) 7TD3 (EM 3.00A ) 7TD4 (EM 2.60A ) 7WF7 (EM 3.40A ) |
| DBSNP | rs4987250 rs11542632 rs7549921 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:29185452}; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization. |
| Mouse PG classification | NA |
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