| Gene Information | |
|---|---|
| Gene Name | EDN3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 238 |
| Protein Names | Endothelin-3 (ET-3) (Preproendothelin-3) (PPET3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000124205 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P14138 |
| Gene Card | EDN3 |
| Uniprot ID | P14138 |
| Pfam | PF00322 |
| In ASD | no |
| Allosteric Prediction | no (-0.040406922) |
| Ortholog in Animals | Alpaca_ EDN3 ( ortholog_one2one ) Dog_ EDN3 ( ortholog_one2one ) GuineaPig_ EDN3 ( ortholog_one2one ) Macaque_ EDN3 ( ortholog_one2one ) Mouse_ Edn3 ( ortholog_one2one ) Rat_ Edn3 ( ortholog_one2one ) Rabbit_ EDN3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EDN1, EDN2 |
| Tissue | small.intestine, spleen, vagina |
| Tissue Specificity | Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells. {ECO:0000269|PubMed:9284755}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.175650(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6IGK (X-ray 2.00A ) |
| DBSNP | rs11570255 rs752400458 rs74315384 rs11570351 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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