| Gene Information | |
|---|---|
| Gene Name | DNASE1L2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 299 |
| Protein Names | Deoxyribonuclease-1-like 2 (EC 3.1.21.-) (DNase I homolog protein DHP1) (Deoxyribonuclease I-like 2) (DNase I-like 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000167968 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q92874 |
| Gene Card | DNASE1L2 |
| Uniprot ID | Q92874 |
| Pfam | PF03372 |
| In ASD | no |
| Allosteric Prediction | no (-1.340595347) |
| Ortholog in Animals | Alpaca_ DNASE1L2 ( ortholog_one2one ) Dog_ DNASE1L2 ( ortholog_one2one ) GuineaPig_ DNASE1L2 ( ortholog_one2one ) Macaque_ DNASE1L2 ( ortholog_one2one ) Mouse_ Dnase1l2 ( ortholog_one2one ) Pig_ DNASE1L2 ( ortholog_one2one ) Rat_ Dnase1l2 ( ortholog_one2one ) Rabbit_ DNASE1L2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DNASE1, DNASE1L1, DNASE1L3 |
| Tissue | zone.of.skin, cerebellum, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | Preferentially expressed in the skin and up-regulated during keratinocytes differentiation. Highly abundant (at protein level) in the stratum granulosum. {ECO:0000269|PubMed:16902420}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16902420}. Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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