| Gene Information | |
|---|---|
| Gene Name | EDAR |
| Organism | Homo sapiens (Human) |
| Gene Length | 448 |
| Protein Names | Tumor necrosis factor receptor superfamily member EDAR (Anhidrotic ectodysplasin receptor 1) (Downless homolog) (EDA-A1 receptor) (Ectodermal dysplasia receptor) (Ectodysplasin-A receptor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000135960 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9UNE0 |
| Gene Card | EDAR |
| Uniprot ID | Q9UNE0 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.382145157) |
| Ortholog in Animals | Alpaca_ EDAR ( ortholog_one2one ) Dog_ EDAR ( ortholog_one2one ) GuineaPig_ EDAR ( ortholog_one2one ) Macaque_ EDAR ( ortholog_one2one ) Mouse_ Edar ( ortholog_one2one ) Pig_ EDAR ( ortholog_one2one ) Rat_ Edar ( ortholog_one2one ) Rabbit_ EDAR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EDA2R, TNFRSF19 |
| Tissue | NA |
| Tissue Specificity | Detected in fetal kidney, lung, skin and cultured neonatal epidermal keratinocytes. Not detected in lymphoblast and fibroblast cell lines. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs778903951 rs121908451 rs121908450 rs144473052 rs121908455 rs886039564 rs3827760 rs1267372612 rs121908454 rs747806672 rs121908453 rs528478080 rs773885029 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | HPG |
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