| Gene Information | |
|---|---|
| Gene Name | EDA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 391 |
| Protein Names | Ectodysplasin-A (Ectodermal dysplasia protein) (EDA protein) [Cleaved into: Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q92838 |
| Gene Card | EDA |
| Uniprot ID | Q92838 |
| Pfam | PF00229 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord. {ECO:0000269|Ref.6}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.035294(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1RJ7 (X-ray 2.30A ) 1RJ8 (X-ray 2.23A ) |
| DBSNP | rs132630308 rs132630311 rs132630319 rs132630309 rs397516662 rs140642493 rs132630312 rs132630313 rs132630314 rs727504649 rs132630315 rs132630316 rs879255552 rs1064793105 rs879255611 rs879255551 rs397516677 rs397516679 rs1602624745 rs142948132 rs132630321 rs132630317 rs876657639 rs61747506 rs132630320 rs1569407346 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:O54693}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O54693}.; [Ectodysplasin-A, secreted form]: Secreted {ECO:0000269|PubMed:11309369, ECO:0000269|PubMed:34582123}. |
| Mouse PG classification | NA |
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