| Gene Information | |
|---|---|
| Gene Name | ECK |
| Organism | Homo sapiens (Human) |
| Gene Length | 976 |
| Protein Names | Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P29317 |
| Gene Card | EPHA2 |
| Uniprot ID | P29317 |
| Pfam | PF14575; PF01404; PF00041; PF07714; PF00536 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung, and ovary. {ECO:0000269|PubMed:17332925}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001899(Rat);0.088889(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1MQB (X-ray 2.30A ) 2E8N (NMR - ) 2K9Y (NMR - ) 2KSO (NMR - ) 2X10 (X-ray 3.00A ) 2X11 (X-ray 4.83A ) 3C8X (X-ray 1.95A ) 3CZU (X-ray 2.65A ) 3FL7 (X-ray 2.50A ) 3HEI (X-ray 2.00A ) 3HPN (X-ray 2.52A ) 3KKA (X-ray 2.40A ) 3MBW (X-ray 2.81A ) 3MX0 (X-ray 3.51A ) 3SKJ (X-ray 2.50A ) 4P2K (X-ray 1.50A ) 4PDO (X-ray 2.10A ) 4TRL (X-ray 2.45A ) 5EK7 (X-ray 1.90A ) 5I9U (X-ray 1.89A ) 5I9V (X-ray 1.46A ) 5I9W (X-ray 1.36A ) 5I9X (X-ray 1.43A ) 5I9Y (X-ray 1.23A ) 5I9Z (X-ray 1.70A ) 5IA0 (X-ray 1.95A ) 5IA1 (X-ray 2.04A ) 5IA2 (X-ray 1.62A ) 5IA3 (X-ray 1.79A ) 5IA4 (X-ray 1.80A ) 5IA5 (X-ray 1.78A ) 5NJZ (X-ray 1.77A ) 5NK0 (X-ray 1.60A ) 5NK1 (X-ray 1.55A ) 5NK2 (X-ray 1.65A ) 5NK3 (X-ray 1.59A ) 5NK4 (X-ray 1.45A ) 5NK5 (X-ray 1.33A ) 5NK6 (X-ray 1.27A ) 5NK7 (X-ray 1.89A ) 5NK8 (X-ray 1.76A ) 5NK9 (X-ray 1.59A ) 5NKA (X-ray 1.38A ) 5NKB (X-ray 1.50A ) 5NKC (X-ray 1.45A ) 5NKD (X-ray 1.41A ) 5NKE (X-ray 1.39A ) 5NKF (X-ray 1.10A ) 5NKG (X-ray 1.10A ) 5NKH (X-ray 1.29A ) 5NKI (X-ray 1.68A ) 5NZ9 (NMR - ) 6B9L (X-ray 3.20A ) 6F7M (NMR - ) 6F7N (NMR - ) 6FNF (X-ray 1.56A ) 6FNG (X-ray 1.04A ) 6FNH (X-ray 1.38A ) 6HES (X-ray 1.13A ) 6HET (X-ray 1.21A ) 6HEU (X-ray 1.72A ) 6HEV (X-ray 1.28A ) 6HEW (X-ray 1.27A ) 6HEX (X-ray 1.41A ) 6HEY (X-ray 1.37A ) 6NJZ (X-ray 1.90A ) 6NK0 (X-ray 1.53A ) 6NK1 (X-ray 1.55A ) 6NK2 (X-ray 2.20A ) 6NKP (X-ray 2.03A ) 6Q7B (X-ray 1.01A ) 6Q7C (X-ray 1.05A ) 6Q7D (X-ray 0.98A ) 6Q7E (X-ray 1.06A ) 6Q7F (X-ray 1.20A ) 6Q7G (X-ray 1.05A ) 6RW2 (X-ray 2.26A ) 7B7N (X-ray 2.69A ) 7CZE (X-ray 3.00A ) 7CZF (X-ray 3.20A ) 7KJA (X-ray 1.75A ) 7KJB (X-ray 2.80A ) 7KJC (X-ray 2.30A ) |
| DBSNP | rs1058372 rs34192549 rs55747232 rs56198600 rs34021505 rs116506614 rs922655349 rs35903225 rs137853200 rs137853199 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18794797, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20223987, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:34067457}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000269|PubMed:19573808}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:19573808}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, focal adhesion {ECO:0000269|PubMed:10655584}. Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:19573808, PubMed:20861311). Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells (PubMed:18794797). {ECO:0000269|PubMed:18794797, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:26158630}. |
| Mouse PG classification | NA |
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