Gene Information
Gene NameLRRC8E
OrganismHomo sapiens (Human)
Gene Length796
Protein NamesVolume-regulated anion channel subunit LRRC8E (Leucine-rich repeat-containing protein 8E)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000171017 )
Evolutionary StageVertebrata
AlphaFoldDBQ6NSJ5
Gene CardLRRC8E
Uniprot IDQ6NSJ5
PfamPF13855; PF12534
In ASDno
Allosteric Predictionno (-0.803534705)
Ortholog in AnimalsAlpaca_ LRRC8E ( ortholog_one2one )
Dog_ LRRC8E ( ortholog_one2one )
GuineaPig_ LRRC8E ( ortholog_one2one )
Macaque_ LRRC8E ( ortholog_one2one )
Mouse_ Lrrc8e ( ortholog_one2one )
Pig_ LRRC8E ( ortholog_one2one )
Rat_ Lrrc8e ( ortholog_one2one )
Rabbit_ LRRC8E ( ortholog_one2one )
OhnologsLRRC8A, LRRC8C, LRRC8D
ParalogsLRRC8B, LRRIQ4, LRRC18, LRCH4, LRRK1, LRRC58, LRRD1, PHLPP1, ERBIN, LRRC8C, LRCH2, MFHAS1, SCRIB, LRRC1, LRRC2, PIDD1, LRRC30, LRRC27, LRRC7, LRCH1, LRRC8A, LRRC8D, LRRC10, LRRC10B, LRRC40, SHOC2, PHLPP2, LRCH3, LRRC69, LRRC39, LRRC28
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs3745377  rs2042919  rs2115108  rs36038711 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731};
Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:24790029}. Lysosome membrane {ECO:0000269|PubMed:33139539};
Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:33139539};
Multi-pass membrane protein {ECO:0000305}. Note=In the absence of LRRC8A, resides primarily in the endoplasmic reticulum (PubMed:24790029, PubMed:33139539). Requires LRRC8A for localization at the cell membrane or lysosome membrane (PubMed:24790029, PubMed:33139539). {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:33139539}.
Mouse PG classificationNA
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