| Gene Information | |
|---|---|
| Gene Name | ECEL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 775 |
| Protein Names | Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000171551 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O95672 |
| Gene Card | ECEL1 |
| Uniprot ID | O95672 |
| Pfam | PF01431; PF05649 |
| In ASD | no |
| Allosteric Prediction | no (-0.828005276) |
| Ortholog in Animals | Alpaca_ ECEL1 ( ortholog_one2one ) Dog_ ECEL1 ( ortholog_one2one ) GuineaPig_ ECEL1 ( ortholog_one2one ) Macaque_ ECEL1 ( ortholog_one2one ) Mouse_ Ecel1 ( ortholog_one2one ) Pig_ ECEL1 ( ortholog_one2one ) Rat_ Ecel1 ( ortholog_one2one ) Rabbit_ ECEL1 ( ortholog_one2one ) |
| Ohnologs | ECE2, MME, MMEL1 |
| Paralogs | KEL, MMEL1, PHEX, ECE1, MME, ECE2 |
| Tissue | ovary, hypothalamus |
| Tissue Specificity | Highly expressed in the CNS, in particular in putamen, spinal cord, medulla and subthalamic nucleus. A strong signal was also detected in uterine subepithelial cells and around renal blood vessels. Detected at lower levels in amygdala, caudate, thalamus, pancreas and skeletal muscle. Detected at very low levels in substantia nigra, cerebellum, cortex, corpus callosum and hippocampus. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2741281 rs1529874 rs532757890 rs587776919 rs587777129 |
| Subcellular location [CC] | Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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