| Gene Information | |
|---|---|
| Gene Name | ECAC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 729 |
| Protein Names | Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transport protein 2) (CaT2) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NQA5 |
| Gene Card | TRPV5 |
| Uniprot ID | Q9NQA5 |
| Pfam | PF00023; PF12796; PF00520 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. {ECO:0000269|PubMed:10945469, ECO:0000269|PubMed:11549322}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5OEO (NMR - ) |
| DBSNP | rs4252372 rs4236480 rs4252499 rs4252509 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:18768590}; Multi-pass membrane protein {ECO:0000269|PubMed:18768590}. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3 (PubMed:18768590). {ECO:0000250|UniProtKB:P69744, ECO:0000269|PubMed:18768590}. |
| Mouse PG classification | NA |
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