| Gene Information | |
|---|---|
| Gene Name | EBP |
| Organism | Homo sapiens (Human) |
| Gene Length | 230 |
| Protein Names | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Delta(8)-Delta(7) sterol isomerase) (D8-D7 sterol isomerase) (Emopamil-binding protein) |
| Target Name | cholestenol delta-isomerase |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000147155 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15125 |
| Gene Card | EBP |
| Uniprot ID | Q15125 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.170691253) |
| Ortholog in Animals | Alpaca_ EBP ( ortholog_one2one ) Dog_ PORCN ( ortholog_one2one ) GuineaPig_ EBP ( ortholog_one2one ) Mouse_ Ebp ( ortholog_one2one ) Pig_ EBP ( ortholog_one2one ) Rat_ Ebp ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EBPL |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6OHT (X-ray 3.20A ) 6OHU (X-ray 3.53A ) |
| DBSNP | rs104894795 rs587783599 rs878854359 rs797045153 rs104894800 rs1602090481 rs28935174 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10406945}; Multi-pass membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000269|PubMed:10406945}. Cytoplasmic vesicle {ECO:0000269|PubMed:10406945}. Note=During interphase, detected on the endoplasmic reticulum and the nuclear envelope. During mitosis, detected on cytoplasmic vesicles. {ECO:0000269|PubMed:10406945}. |
| Mouse PG classification | LPG |
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