| Gene Information | |
|---|---|
| Gene Name | DSHP |
| Organism | Homo sapiens (Human) |
| Gene Length | 128 |
| Protein Names | SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O60880 |
| Gene Card | SH2D1A |
| Uniprot ID | O60880 |
| Pfam | PF00017 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T-lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis. {ECO:0000269|PubMed:11282995}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1D1Z (X-ray 1.40A ) 1D4T (X-ray 1.10A ) 1D4W (X-ray 1.80A ) 1KA6 (NMR - ) 1KA7 (NMR - ) 1M27 (X-ray 2.50A ) |
| DBSNP | rs1569527111 rs111033624 rs111033630 rs111033627 rs111033626 |
| Subcellular location [CC] | Cytoplasm {ECO:0000305}. |
| Mouse PG classification | NA |
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