| Gene Information | |
|---|---|
| Gene Name | EAAT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 542 |
| Protein Names | Excitatory amino acid transporter 1 (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P43003 |
| Gene Card | SLC1A3 |
| Uniprot ID | P43003 |
| Pfam | PF00375 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in brain (PubMed:8218410, PubMed:7521911, PubMed:8123008). Detected at very much lower levels in heart, lung, placenta and skeletal muscle (PubMed:7521911, PubMed:8123008). Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia (PubMed:7521911). {ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:8123008, ECO:0000269|PubMed:8218410}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5LLM (X-ray 3.25A ) 5LLU (X-ray 3.32A ) 5LM4 (X-ray 3.10A ) 5MJU (X-ray 3.71A ) 7NPW (EM 3.99A ) |
| DBSNP | rs2032892 rs137852619 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20477940, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:8123008}; Multi-pass membrane protein {ECO:0000269|PubMed:28424515}. |
| Mouse PG classification | NA |
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