Gene Information | |
---|---|
Gene Name | DYRK3 |
Organism | Homo sapiens (Human) |
Gene Length | 588 |
Protein Names | Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1) (Regulatory erythroid kinase) (REDK) |
Target Name | dual-specificity tyrosine-phosphorylation regulated kinase 3 |
Target Type | Patented-recorded target |
Gene Age | >4290 ( ENSG00000143479 ) |
Evolutionary Stage | Eukaryota |
AlphaFoldDB | O43781 |
Gene Card | DYRK3 |
Uniprot ID | O43781 |
Pfam | PF00069 |
In ASD | no |
Allosteric Prediction | yes (0.472122731) |
Ortholog in Animals | Alpaca_ DYRK3 ( ortholog_one2one ) GuineaPig_ DYRK3 ( ortholog_one2one ) Macaque_ DYRK3 ( ortholog_one2one ) Mouse_ Dyrk3 ( ortholog_one2one ) Pig_ DYRK3 ( ortholog_one2one ) Rat_ Dyrk3 ( ortholog_one2one ) Rabbit_ DYRK3 ( ortholog_one2one ) |
Ohnologs | DYRK2 |
Paralogs | CLK1, HIPK3, DYRK4, DYRK1B, HIPK1, CLK3, HIPK4, HIPK2, CLK4, DYRK2, DYRK1A, CLK2 |
Tissue | testis |
Tissue Specificity | Isoform 1: Highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow (PubMed:10779429). Isoform 1: Predominant form in fetal liver and bone marrow (PubMed:10779429). Isoform 1: Present at low levels in heart, pancreas, lymph node and thymus (PubMed:10779429). Isoform 2: Highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow (PubMed:10779429). Isoform 2: Predominant form in testis. Isoform 2: Present at low levels in heart, pancreas, lymph node and thymus (PubMed:10779429). {ECO:0000269|PubMed:10779429}. |
Pharmacological Animal Models | NA |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | 5Y86 (X-ray 1.90A ) |
DBSNP | NA |
Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10779429, ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:29973724}. Cytoplasm {ECO:0000269|PubMed:29973724}. Nucleus speckle {ECO:0000269|PubMed:29973724}. Cytoplasmic granule {ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:23415227, ECO:0000269|PubMed:29973724}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:29973724}. Note=Associates with membraneless organelles in the cytoplasm and nucleus (PubMed:29973724). Shuttles between cytoplasm and stress granules (PubMed:20167603). Localized predominantly on distinct speckles distributed throughout the cytoplasm of the cell (PubMed:20167603). At low concentration, showns a homogeneous distribution throughout the cytoplasm and does not condense in speckles. During oxidative and osmotic stress, localizes to stress granules (PubMed:20167603). {ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:29973724}. |
Mouse PG classification | NA |
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