Gene Information
Gene NameDYRK3
OrganismHomo sapiens (Human)
Gene Length588
Protein NamesDual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1) (Regulatory erythroid kinase) (REDK)
Target Namedual-specificity tyrosine-phosphorylation regulated kinase 3
Target TypePatented-recorded target
Gene Age>4290 ( ENSG00000143479 )
Evolutionary StageEukaryota
AlphaFoldDBO43781
Gene CardDYRK3
Uniprot IDO43781
PfamPF00069
In ASDno
Allosteric Predictionyes (0.472122731)
Ortholog in AnimalsAlpaca_ DYRK3 ( ortholog_one2one )
GuineaPig_ DYRK3 ( ortholog_one2one )
Macaque_ DYRK3 ( ortholog_one2one )
Mouse_ Dyrk3 ( ortholog_one2one )
Pig_ DYRK3 ( ortholog_one2one )
Rat_ Dyrk3 ( ortholog_one2one )
Rabbit_ DYRK3 ( ortholog_one2one )
OhnologsDYRK2
ParalogsCLK1, HIPK3, DYRK4, DYRK1B, HIPK1, CLK3, HIPK4, HIPK2, CLK4, DYRK2, DYRK1A, CLK2
Tissuetestis
Tissue SpecificityIsoform 1: Highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow (PubMed:10779429). Isoform 1: Predominant form in fetal liver and bone marrow (PubMed:10779429). Isoform 1: Present at low levels in heart, pancreas, lymph node and thymus (PubMed:10779429). Isoform 2: Highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow (PubMed:10779429). Isoform 2: Predominant form in testis. Isoform 2: Present at low levels in heart, pancreas, lymph node and thymus (PubMed:10779429). {ECO:0000269|PubMed:10779429}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5Y86  (X-ray  1.90A 
DBSNP NA 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:10779429, ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:29973724}. Cytoplasm {ECO:0000269|PubMed:29973724}. Nucleus speckle {ECO:0000269|PubMed:29973724}. Cytoplasmic granule {ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:23415227, ECO:0000269|PubMed:29973724}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:29973724}. Note=Associates with membraneless organelles in the cytoplasm and nucleus (PubMed:29973724). Shuttles between cytoplasm and stress granules (PubMed:20167603). Localized predominantly on distinct speckles distributed throughout the cytoplasm of the cell (PubMed:20167603). At low concentration, showns a homogeneous distribution throughout the cytoplasm and does not condense in speckles. During oxidative and osmotic stress, localizes to stress granules (PubMed:20167603). {ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:29973724}.
Mouse PG classificationNA
click here to return to the previous page