| Gene Information | |
|---|---|
| Gene Name | SLC27A2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 620 |
| Protein Names | Long-chain fatty acid transport protein 2 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Phytanate--CoA ligase) (EC 6.2.1.24) (Solute carrier family 27 member 2) (THCA-CoA ligase) (EC 6.2.1.7) (Very long-chain acyl-CoA synthetase) (VLACS) (VLCS) (EC 6.2.1.-) (Very long-chain-fatty-acid-CoA ligase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000140284 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O14975 |
| Gene Card | SLC27A2 |
| Uniprot ID | O14975 |
| Pfam | PF00501; PF13193 |
| In ASD | no |
| Allosteric Prediction | yes (0.184216849) |
| Ortholog in Animals | Alpaca_ SLC27A2 ( ortholog_one2one ) Dog_ SLC27A2 ( ortholog_one2one ) GuineaPig_ SLC27A2 ( ortholog_one2one ) Macaque_ SLC27A2 ( ortholog_one2one ) Mouse_ Slc27a2 ( ortholog_one2one ) Pig_ SLC27A2 ( ortholog_one2one ) Rat_ Slc27a2 ( ortholog_one2one ) Rabbit_ SLC27A2 ( ortholog_one2one ) |
| Ohnologs | SLC27A6, SLC27A3 |
| Paralogs | SLC27A4, ACSBG1, ACSL1, ACSL3, SLC27A3, ACSL6, ACSBG2, SLC27A6, ACSL4, ACSL5, SLC27A1, SLC27A5 |
| Tissue | liver |
| Tissue Specificity | [Isoform 1]: Expressed in liver, kidney, placenta, intestine, brain, heart, and colon (PubMed:10198260, PubMed:21768100, PubMed:24269233). Predominantly expressed in liver (PubMed:20530735). {ECO:0000269|PubMed:10198260, ECO:0000269|PubMed:20530735, ECO:0000269|PubMed:21768100, ECO:0000269|PubMed:24269233}.; [Isoform 2]: Expressed in liver, placenta, and intestine, but much lower relative to isoform 1. {ECO:0000269|PubMed:21768100}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs1648348 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:11980911, ECO:0000269|PubMed:22022213, ECO:0000269|PubMed:24269233}; Multi-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000269|PubMed:10198260, ECO:0000269|PubMed:10640429}; Peripheral membrane protein {ECO:0000269|PubMed:10640429}. Cell membrane {ECO:0000269|PubMed:20530735}; Multi-pass membrane protein {ECO:0000255}. Microsome {ECO:0000269|PubMed:10640429}. |
| Mouse PG classification | NA |
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