Gene Information
Gene NamePKD1
OrganismHomo sapiens (Human)
Gene Length912
Protein NamesSerine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)
Target NameNA
Target TypeNA
Gene Age1064 ( ENSG00000008710 )
Evolutionary StageEumetazoa
AlphaFoldDBQ15139
Gene CardPRKD1
Uniprot IDQ15139
PfamPF00130; PF00169; PF00069
In ASDno
Allosteric Predictionyes (0.456264521)
Ortholog in AnimalsGuineaPig_ PKD1 ( ortholog_one2one )
Macaque_ PKD1 ( ortholog_one2one )
Mouse_ Pkd1 ( ortholog_one2one )
Pig_ PKD1 ( ortholog_one2one )
Rat_ Pkd1 ( ortholog_one2one )
OhnologsNA
ParalogsPKDREJ, PKD1L2, PKD2L2, DENND5B, DENND5A, PKD2L1, LOXHD1, PKD1L3, PKD1L1, PKD2
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs1383618278  rs1057519636  rs55852813  rs1057519635  rs34588699  rs11161065  rs45582934 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:18076381}. Cell membrane {ECO:0000269|PubMed:18076381}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q62101}. Note=Translocation to the cell membrane is required for kinase activation.
Mouse PG classificationHPG
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