| Gene Information | |
|---|---|
| Gene Name | DVL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 736 |
| Protein Names | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000004975 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O14641 |
| Gene Card | DVL2 |
| Uniprot ID | O14641 |
| Pfam | PF00610; PF02377; PF00778; PF12316; PF00595 |
| In ASD | no |
| Allosteric Prediction | no (-0.212629886) |
| Ortholog in Animals | Alpaca_ DVL2 ( ortholog_one2one ) Dog_ DVL2 ( ortholog_one2one ) GuineaPig_ DVL2 ( ortholog_one2one ) Macaque_ DVL2 ( ortholog_one2one ) Mouse_ Dvl2 ( ortholog_one2one ) Pig_ DVL2 ( ortholog_one2one ) Rat_ Dvl2 ( ortholog_one2one ) Rabbit_ DVL2 ( ortholog_one2one ) |
| Ohnologs | DVL1, DVL3 |
| Paralogs | DIXDC1, DVL1, DVL3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001920(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2REY (X-ray 1.55A ) 3CBX (X-ray 1.70A ) 3CBY (X-ray 1.50A ) 3CBZ (X-ray 1.38A ) 3CC0 (X-ray 1.75A ) 4WIP (X-ray 2.69A ) 5LNP (X-ray 1.99A ) 5SUY (X-ray 1.88A ) 5SUZ (X-ray 1.84A ) 6IW3 (X-ray 1.64A ) 6JCK (X-ray 3.09A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q60838}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q60838}; Cytoplasmic side {ECO:0000250|UniProtKB:Q60838}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q60838}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q60838}. Nucleus {ECO:0000269|PubMed:25805136}. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136). {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:25805136}. |
| Mouse PG classification | NA |
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