| Gene Information | |
|---|---|
| Gene Name | DUT |
| Organism | Homo sapiens (Human) |
| Gene Length | 252 |
| Protein Names | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) |
| Target Name | dutp pyrophosphatase |
| Target Type | Clinical trial target |
| Gene Age | 1292 ( ENSG00000128951 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P33316 |
| Gene Card | DUT |
| Uniprot ID | P33316 |
| Pfam | PF00692 |
| In ASD | no |
| Allosteric Prediction | yes (0.507421742) |
| Ortholog in Animals | Alpaca_ DUT ( ortholog_one2one ) Dog_ DUT ( ortholog_one2one ) GuineaPig_ DUT ( ortholog_one2one ) Mouse_ Dut ( ortholog_one2one ) Pig_ DUT ( ortholog_one2one ) Rat_ Dut ( ortholog_one2many ) Rat_ AABR07001512.1 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level). {ECO:0000269|PubMed:9228092}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1Q5H (X-ray 2.00A ) 1Q5U (X-ray 2.00A ) 2HQU (X-ray 2.20A ) 3ARA (X-ray 1.70A ) 3ARN (X-ray 1.80A ) 3EHW (X-ray 1.80A ) 4MZ5 (X-ray 2.10A ) 4MZ6 (X-ray 1.88A ) 5H4J (X-ray 1.80A ) |
| DBSNP | rs28381104 |
| Subcellular location [CC] | [Isoform 2]: Nucleus {ECO:0000269|PubMed:8631816, ECO:0000269|PubMed:9070952}.; [Isoform 3]: Mitochondrion {ECO:0000269|PubMed:8631816, ECO:0000269|PubMed:9070952}. |
| Mouse PG classification | NA |
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