| Gene Information | |
|---|---|
| Gene Name | DUSP8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 625 |
| Protein Names | Dual specificity protein phosphatase 8 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH-5) |
| Target Name | dusp8 messenger rna |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000184545 ) 3 ( ENSG00000273793 ) 3 ( ENSG00000278165 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q13202 |
| Gene Card | DUSP8 |
| Uniprot ID | Q13202 |
| Pfam | PF00782; PF00581 |
| In ASD | no |
| Allosteric Prediction | no (-0.361854697) |
| Ortholog in Animals | GuineaPig_ DUSP8 ( ortholog_one2one ) Macaque_ DUSP8 ( ortholog_one2one ) Mouse_ Dusp8 ( ortholog_one2one ) Pig_ DUSP8 ( ortholog_one2one ) Rat_ Dusp8 ( ortholog_one2one ) |
| Ohnologs | DUSP16 |
| Paralogs | DUSP6, DUSP4, DUSP12, DUSP10, STYXL2, SSH3, DUSP19, DUSP1, KASH5, SSH1, DUSP29, DUSP16, DUSP21, DUSP2, DUSP13, EPM2A, DUSP7, DUSP26, STYX, SSH2, PTPMT1, DUSP22, DUSP18, DUSP15, DUSP14, DUSP28, STYXL1, DUSP5, DUSP9, DUSP3 |
| Tissue | NA |
| Tissue Specificity | Abundant in brain, heart and skeletal muscle. {ECO:0000269|PubMed:7561881}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4JMK (X-ray 1.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:O09112}. Nucleus {ECO:0000250|UniProtKB:O09112}. |
| Mouse PG classification | NA |
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