| Gene Information | |
|---|---|
| Gene Name | SLC1A4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 532 |
| Protein Names | Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter 1) (ASCT-1) (Solute carrier family 1 member 4) |
| Target Name | neutral amino acid transporter a |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000115902 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P43007 |
| Gene Card | SLC1A4 |
| Uniprot ID | P43007 |
| Pfam | PF00375 |
| In ASD | no |
| Allosteric Prediction | yes (0.328669166) |
| Ortholog in Animals | Alpaca_ SLC1A4 ( ortholog_one2one ) Dog_ SLC1A4 ( ortholog_one2one ) GuineaPig_ SLC1A4 ( ortholog_one2one ) Macaque_ SLC1A4 ( ortholog_one2one ) Mouse_ Slc1a4 ( ortholog_one2one ) Pig_ SLC1A4 ( ortholog_one2one ) Rat_ Slc1a4 ( ortholog_one2one ) |
| Ohnologs | SLC1A6, SLC1A5 |
| Paralogs | SLC1A6, SLC1A2, SLC1A7, SLC1A1, SLC1A5, SLC1A3 |
| Tissue | NA |
| Tissue Specificity | Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined. {ECO:0000269|PubMed:8340364}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7P4I (EM 4.20A ) |
| DBSNP | rs1064512 rs201278558 rs759458 rs761533681 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:17081065}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}. |
| Mouse PG classification | NA |
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