Gene Information
Gene NameLAMP5
OrganismHomo sapiens (Human)
Gene Length280
Protein NamesLysosome-associated membrane glycoprotein 5 (Brain and dendritic cell-associated LAMP) (Brain-associated LAMP-like protein) (BAD-LAMP) (Lysosome-associated membrane protein 5) (LAMP-5)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000125869 )
Evolutionary StageVertebrata
AlphaFoldDBQ9UJQ1
Gene CardLAMP5
Uniprot IDQ9UJQ1
PfamPF01299
In ASDno
Allosteric Predictionno (-1.475801663)
Ortholog in AnimalsAlpaca_ LAMP5 ( ortholog_one2one )
Dog_ LAMP5 ( ortholog_one2one )
GuineaPig_ LAMP5 ( ortholog_one2one )
Macaque_ LAMP5 ( ortholog_one2one )
Mouse_ Lamp5 ( ortholog_one2one )
Pig_ LAMP5 ( ortholog_one2one )
Rat_ Lamp5 ( ortholog_one2one )
Rabbit_ LAMP5 ( ortholog_one2one )
OhnologsNA
ParalogsLAMP2, LAMP1, CD68
Tissuebrain, ovary, cerebral.cortex, lymph.node, oviduct, nucleus.accumbens
Tissue SpecificityExpressed in plasmocytoid dendritic cells. Expressed in suprabasal skin keratinocytes and squamous cells (at protein level). Expressed in the brain and weakly in spleen and skin. Expressed in plasmocytoid dendritic cells. {ECO:0000269|PubMed:21642595}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs2232259  rs2232263  rs2232264  rs2232266 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:21642595};
Single-pass type I membrane protein {ECO:0000269|PubMed:21642595}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9D387};
Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:21642595};
Single-pass type I membrane protein {ECO:0000269|PubMed:21642595}. Endosome membrane {ECO:0000269|PubMed:21642595};
Single-pass type I membrane protein {ECO:0000269|PubMed:21642595}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9D387};
Single-pass type I membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9D387}. Cell projection, growth cone membrane {ECO:0000250|UniProtKB:Q9D387};
Single-pass type I membrane protein {ECO:0000305}. Early endosome membrane {ECO:0000250|UniProtKB:Q9D387};
Single-pass type I membrane protein {ECO:0000305}. Recycling endosome {ECO:0000250|UniProtKB:Q9D387}. Note=Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (By similarity). Colocalizes with UNC93B1 in large endosomal intracellular vesicles (PubMed:21642595). Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides (PubMed:21642595). Associates with cortical membranes (PubMed:21642595). Localizes mostly in cytoplasmic vesicles of neuronal cell body (By similarity). Localizes to synaptic vesicles in a subset of GABAergic neurons (By similarity). {ECO:0000250|UniProtKB:Q9D387, ECO:0000269|PubMed:21642595}.
Mouse PG classificationNA
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