| Gene Information | |
|---|---|
| Gene Name | DUSP12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 340 |
| Protein Names | Dual specificity protein phosphatase 12 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity tyrosine phosphatase YVH1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000081721 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UNI6 |
| Gene Card | DUSP12 |
| Uniprot ID | Q9UNI6 |
| Pfam | PF00782 |
| In ASD | no |
| Allosteric Prediction | no (-0.731693593) |
| Ortholog in Animals | Alpaca_ DUSP12 ( ortholog_one2one ) Dog_ DUSP12 ( ortholog_one2one ) GuineaPig_ DUSP12 ( ortholog_one2one ) Mouse_ Dusp12 ( ortholog_one2one ) Pig_ DUSP12 ( ortholog_one2one ) Rat_ Dusp12 ( ortholog_one2one ) Rabbit_ DUSP12 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DUSP6, DUSP4, DUSP10, STYXL2, SSH3, DUSP19, DUSP1, KASH5, SSH1, DUSP29, DUSP16, DUSP21, DUSP2, DUSP8, DUSP13, EPM2A, DUSP7, DUSP26, STYX, SSH2, PTPMT1, DUSP22, DUSP18, DUSP15, DUSP14, DUSP28, STYXL1, DUSP5, DUSP9, DUSP3 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous, highest expression in spleen, testis, ovary, and peripheral blood leukocytes and lower expression in liver and lung. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001899(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4JNB (X-ray 3.00A ) 4KI9 (X-ray 2.00A ) |
| DBSNP | rs35106830 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10446167}. Cytoplasm, cytosol {ECO:0000269|PubMed:10446167}. Note=Primarily nuclear. Detected in a mesh-like pattern in the cytosol. {ECO:0000269|PubMed:10446167}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |