Gene Information
Gene NameCYP2E1
OrganismHomo sapiens (Human)
Gene Length493
Protein NamesCytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J)
Target Namecytochrome p450 2e1
Target TypeNA
Gene Age382 ( ENSG00000130649 )
Evolutionary StageEukaryota
AlphaFoldDBP05181
Gene CardCYP2E1
Uniprot IDP05181
PfamPF00067
In ASDyes
Allosteric Predictionyes (1.032546617)
Ortholog in AnimalsAlpaca_ CYP2E1 ( ortholog_one2one )
Dog_ CYP2E1 ( ortholog_one2one )
GuineaPig_ CYP2E1 ( ortholog_one2one )
Mouse_ Cyp2e1 ( ortholog_one2one )
Pig_ CYP2E1 ( ortholog_one2one )
Rat_ Cyp2e1 ( ortholog_one2one )
Rabbit_ CYP2E1 ( ortholog_one2one )
OhnologsCYP2U1
ParalogsCYP2S1, CYP2W1, CYP2D6, CYP2C18, CYP2C9, CYP2C19, CYP2B6, CYP2C8, CYP2U1, CYP2A6, CYP2A7, CYP2A13, CYP2F1, CYP2R1, CYP2J2
Tissueliver
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3E4E  (X-ray  2.60A  )  3E6I  (X-ray  2.20A  )  3GPH  (X-ray  2.70A  )  3KOH  (X-ray  2.90A  )  3LC4  (X-ray  3.10A  )  3T3Z  (X-ray  2.35A  ) 
DBSNP rs72559710  rs6413419  rs41299426  rs41299434  rs55897648  rs28969387 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P05182};
Peripheral membrane protein {ECO:0000250|UniProtKB:P05182}. Microsome membrane {ECO:0000250|UniProtKB:P05182};
Peripheral membrane protein {ECO:0000250|UniProtKB:P05182}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P05182};
Peripheral membrane protein {ECO:0000250|UniProtKB:P05182}. Note=Post-translationally targeted to mitochondria. TOMM70 is required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein. {ECO:0000250|UniProtKB:P05182}.
Mouse PG classificationNA
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