| Gene Information | |
|---|---|
| Gene Name | DTX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 620 |
| Protein Names | E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000135144 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q86Y01 |
| Gene Card | DTX1 |
| Uniprot ID | Q86Y01 |
| Pfam | PF18102; PF02825; PF00097 |
| In ASD | no |
| Allosteric Prediction | no (-0.205750246) |
| Ortholog in Animals | Alpaca_ DTX1 ( ortholog_one2one ) Dog_ DTX1 ( ortholog_one2one ) Macaque_ DTX1 ( ortholog_one2one ) Mouse_ Dtx1 ( ortholog_one2one ) Pig_ DTX1 ( ortholog_one2one ) Rat_ Dtx1 ( ortholog_one2one ) |
| Ohnologs | DTX2, DTX4 |
| Paralogs | DTX4, DTX3L, DTX3, DTX2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells. {ECO:0000269|PubMed:12753744, ECO:0000269|PubMed:9590294}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6Y5N (X-ray 1.88A ) 6Y5P (X-ray 1.74A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear. |
| Mouse PG classification | NA |
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