| Gene Information | |
|---|---|
| Gene Name | S1PR4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 384 |
| Protein Names | Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6) |
| Target Name | sphingosine 1-phosphate receptor 4 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000125910 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95977 |
| Gene Card | S1PR4 |
| Uniprot ID | O95977 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (0.959632863) |
| Ortholog in Animals | Dog_ S1PR4 ( ortholog_one2one ) Mouse_ S1pr4 ( ortholog_one2one ) Pig_ S1PR4 ( ortholog_one2one ) Rat_ S1pr4 ( ortholog_one2one ) |
| Ohnologs | S1PR5, LPAR2, S1PR1, LPAR3, LPAR1, S1PR3 |
| Paralogs | GPR3, GPR119, GPR6, GPR12, CNR1, CNR2, MC5R, MC1R, MC2R, MC3R, MC4R, LPAR1, LPAR2, LPAR3, S1PR1, S1PR5, S1PR2, S1PR3 |
| Tissue | bone.marrow, spleen, lung, whole.blood |
| Tissue Specificity | Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DCO (NMR - ) |
| DBSNP | rs3746072 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
| click here to return to the previous page | |