| Gene Information | |
|---|---|
| Gene Name | DTNA |
| Organism | Homo sapiens (Human) |
| Gene Length | 743 |
| Protein Names | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000134769 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y4J8 |
| Gene Card | DTNA |
| Uniprot ID | Q9Y4J8 |
| Pfam | PF09068; PF09069; PF00569 |
| In ASD | no |
| Allosteric Prediction | yes (0.323744317) |
| Ortholog in Animals | Alpaca_ DTNA ( ortholog_one2one ) Dog_ DTNA ( ortholog_one2one ) GuineaPig_ DTNA ( ortholog_one2one ) Macaque_ DTNA ( ortholog_one2one ) Mouse_ Dtna ( ortholog_one2one ) Pig_ DTNA ( ortholog_one2one ) Rat_ Dtna ( ortholog_one2one ) Rabbit_ DTNA ( ortholog_one2one ) |
| Ohnologs | DTNB |
| Paralogs | DSP, SPTBN5, ACTN4, MICAL2, DMD, SYNE3, GAS2L2, SPTBN2, FLNB, SPTAN1, SYNE2, PLEC, EPPK1, SYNE1, CLMN, DYTN, MICAL3, PKHD1, SMTNL2, DRP2, UTRN, PKHD1L1, ACTN2, ACTN3, MICAL1, SPTBN1, MACF1, ACTN1, DST, SPTB, GAS2L3, FLNC, FLNA, SPTA1, DTNB, SPTBN4 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain, skeletal and cardiac muscles, and expressed at lower levels in lung, liver and pancreas. Isoform 2 is not expressed in cardiac muscle. Isoform 7 and isoform 8 are only expressed in muscle. |
| Pharmacological Animal Models | 0.077131(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2E5R (NMR - ) |
| DBSNP | rs104894654 rs1048081 |
| Subcellular location [CC] | Cytoplasm. Synapse. Cell membrane {ECO:0000250}. Note=In peripheral nerves, colocalizes with MAGEE1 in the Schwann cell membrane. {ECO:0000250}. |
| Mouse PG classification | HPG |
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