| Gene Information | |
|---|---|
| Gene Name | DTL |
| Organism | Homo sapiens (Human) |
| Gene Length | 730 |
| Protein Names | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000143476 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NZJ0 |
| Gene Card | DTL |
| Uniprot ID | Q9NZJ0 |
| Pfam | PF00400 |
| In ASD | no |
| Allosteric Prediction | no (-0.131145053) |
| Ortholog in Animals | Alpaca_ DTL ( ortholog_one2one ) Dog_ DTL ( ortholog_one2one ) GuineaPig_ DTL ( ortholog_one2one ) Macaque_ DTL ( ortholog_one2one ) Mouse_ Dtl ( ortholog_one2one ) Pig_ DTL ( ortholog_one2one ) Rat_ Dtl ( ortholog_one2one ) Rabbit_ DTL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | testis, brain, spleen |
| Tissue Specificity | Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell. {ECO:0000269|PubMed:11278750, ECO:0000269|PubMed:17106265}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003490(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 6QC0 (X-ray 3.50A ) |
| DBSNP | rs35137676 rs3135474 rs6540718 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:26431207}. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome. Note=Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis. |
| Mouse PG classification | NA |
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