| Gene Information | |
|---|---|
| Gene Name | DSP |
| Organism | Homo sapiens (Human) |
| Gene Length | 2871 |
| Protein Names | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) |
| Target Name | desmoplakin |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000096696 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | NA |
| Gene Card | DSP |
| Uniprot ID | P15924 |
| Pfam | PF00681; PF17902; PF18373 |
| In ASD | no |
| Allosteric Prediction | yes (0.558625085) |
| Ortholog in Animals | Alpaca_ DSP ( ortholog_one2one ) Dog_ DSP ( ortholog_one2one ) GuineaPig_ DSP ( ortholog_one2one ) Macaque_ DSP ( ortholog_one2one ) Mouse_ Dsp ( ortholog_one2one ) Pig_ DSP ( ortholog_one2one ) Rat_ Dsp ( ortholog_one2one ) Rabbit_ DSP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SPTBN5, ACTN4, MICAL2, DMD, SYNE3, GAS2L2, SPTBN2, FLNB, SPTAN1, SYNE2, PLEC, EPPK1, SYNE1, CLMN, DYTN, MICAL3, PKHD1, SMTNL2, DRP2, UTRN, PKHD1L1, ACTN2, ACTN3, MICAL1, SPTBN1, MACF1, ACTN1, DST, SPTB, GAS2L3, FLNC, FLNA, DTNA, SPTA1, DTNB, SPTBN4 |
| Tissue | heart, left.ventricle, placenta |
| Tissue Specificity | Expressed in oral mucosa (at protein level) (PubMed:30479852). Expressed in arrector pili muscle (at protein level) (PubMed:29034528). {ECO:0000269|PubMed:29034528, ECO:0000269|PubMed:30479852}.; [Isoform DPI]: Apparently an obligate constituent of all desmosomes.; [Isoform DPII]: Resides predominantly in tissues and cells of stratified origin. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.018182(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1LM5 (X-ray 1.80A ) 1LM7 (X-ray 3.00A ) 3R6N (X-ray 2.95A ) 5DZZ (X-ray 2.60A ) |
| DBSNP | rs121912993 rs121912992 rs17604693 rs934142779 rs606231295 rs606231294 rs777407386 rs375919492 rs2076299 rs28763966 rs28763967 rs6929069 rs34738426 rs78652302 rs28931610 rs376923069 |
| Subcellular location [CC] | Cell junction, desmosome {ECO:0000250|UniProtKB:E9Q557}. Cell membrane {ECO:0000250|UniProtKB:E9Q557}. Note=Localizes at the intercalated disk in cardiomyocytes. {ECO:0000250|UniProtKB:E9Q557}. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |