| Gene Information | |
|---|---|
| Gene Name | DSG2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1118 |
| Protein Names | Desmoglein-2 (Cadherin family member 5) (HDGC) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000046604 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q14126 |
| Gene Card | DSG2 |
| Uniprot ID | Q14126 |
| Pfam | PF00028 |
| In ASD | no |
| Allosteric Prediction | yes (0.089266158) |
| Ortholog in Animals | Alpaca_ DSG2 ( ortholog_one2one ) Dog_ DSG3 ( ortholog_one2one ) GuineaPig_ DSG2 ( ortholog_one2one ) Macaque_ DSG2 ( ortholog_one2one ) Mouse_ Dsg2 ( ortholog_one2one ) Pig_ DSG2 ( ortholog_one2one ) Rat_ Dsg2 ( ortholog_one2one ) Rabbit_ DSG2 ( ortholog_one2one ) |
| Ohnologs | CDH3, CDH15, CDH13 |
| Paralogs | DSG1, DSG3, DSG4, DSC2, DSC1, DSC3 |
| Tissue | NA |
| Tissue Specificity | All of the tissues tested and carcinomas. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2YQG (NMR - ) 5ERD (X-ray 2.90A ) 5J5J (X-ray 3.29A ) 6QNT (EM 3.50A ) 6QNU (EM 3.80A ) 6SIT (X-ray 4.50A ) 7A7D (EM 26.00A ) 7AGF (EM 3.10A ) 7AGG (EM 3.30A ) |
| DBSNP | rs121913008 rs121913006 rs121913013 rs2230232 rs191143292 rs2230234 rs191564916 rs121913009 rs2230235 rs79241126 rs2278792 rs121913010 rs16962093 rs34065672 rs142841727 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:31402609}; Single-pass type I membrane protein. Cell junction, desmosome {ECO:0000269|PubMed:31402609}. |
| Mouse PG classification | LPG |
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