| Gene Information | |
|---|---|
| Gene Name | DSE |
| Organism | Homo sapiens (Human) |
| Gene Length | 958 |
| Protein Names | Dermatan-sulfate epimerase (DS epimerase) (EC 5.1.3.19) (Chondroitin-glucuronate 5-epimerase) (Squamous cell carcinoma antigen recognized by T-cells 2) (SART-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000111817 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UL01 |
| Gene Card | DSE |
| Uniprot ID | Q9UL01 |
| Pfam | PF16332 |
| In ASD | no |
| Allosteric Prediction | no (-0.642952209) |
| Ortholog in Animals | Alpaca_ DSE ( ortholog_one2one ) Dog_ DSE ( ortholog_one2one ) GuineaPig_ DSE ( ortholog_one2one ) Macaque_ DSE ( ortholog_one2one ) Mouse_ Dse ( ortholog_one2one ) Pig_ DSE ( ortholog_one2one ) Rat_ Dse ( ortholog_one2one ) Rabbit_ DSE ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DSEL |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed with higher expression in kidney and ovary and lower expression in brain, colon and thymus. Also expressed in renal cell carcinomas, brain tumors, and in a part of melanomas and adenocarcinomas from organs other than the breast. Expressed in squamous cell carcinomas (SCC), glioma, and some adenocarcinoma cell lines, but not in breast cancer cell lines or any normal tissues (at protein level). {ECO:0000269|PubMed:10679095}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6HZN (X-ray 2.41A ) |
| DBSNP | rs10485183 rs35548455 rs398122361 rs34994230 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10679095, ECO:0000305|PubMed:7092807}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:10679095}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10679095}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000269|PubMed:7092807}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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