| Gene Information | |
|---|---|
| Gene Name | MAPKAPK5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 473 |
| Protein Names | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) |
| Target Name | map kinase-activated protein kinase 5 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000089022 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8IW41 |
| Gene Card | MAPKAPK5 |
| Uniprot ID | Q8IW41 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.416931256) |
| Ortholog in Animals | Alpaca_ MAPKAPK5 ( ortholog_one2one ) Dog_ MAPKAPK5 ( ortholog_one2one ) GuineaPig_ MAPKAPK5 ( ortholog_one2one ) Macaque_ MAPKAPK5 ( ortholog_one2one ) Mouse_ Mapkapk5 ( ortholog_one2one ) Pig_ MAPKAPK5 ( ortholog_one2one ) Rabbit_ MAPKAPK5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MKNK1, MAPKAPK2, MKNK2, CAMK4, DCX, MAPKAPK3 |
| Tissue | NA |
| Tissue Specificity | Expressed ubiquitously. {ECO:0000269|PubMed:9628874}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34132040 rs34843470 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export. |
| Mouse PG classification | NA |
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