| Gene Information | |
|---|---|
| Gene Name | DRD5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 477 |
| Protein Names | D(1B) dopamine receptor (D(5) dopamine receptor) (D1beta dopamine receptor) (Dopamine D5 receptor) |
| Target Name | dopamine d5 receptor |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000169676 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P21918 |
| Gene Card | DRD5 |
| Uniprot ID | P21918 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.209200377) |
| Ortholog in Animals | Alpaca_ DRD5 ( ortholog_one2one ) Dog_ DRD5 ( ortholog_one2one ) GuineaPig_ DRD5 ( ortholog_one2one ) Macaque_ DRD5 ( ortholog_one2one ) Mouse_ Drd5 ( ortholog_one2one ) Pig_ DRD5 ( ortholog_one2one ) Rat_ Drd5 ( ortholog_one2one ) Rabbit_ DRD5 ( ortholog_one2one ) |
| Ohnologs | HRH2, ADRA1A, HTR4, ADRA1B, DRD1 |
| Paralogs | HRH2, TAAR6, DRD4, HRH1, DRD1, GPR52, HTR1A, HTR1D, CHRM3, CHRM4, HRH3, TAAR5, HTR4, TAAR1, GPR21, CHRM1, HRH4, TAAR9, CHRM5, TAAR8, DRD3, GPR84, CHRM2, GPR161, TAAR2 |
| Tissue | NA |
| Tissue Specificity | Neuron-specific, localized primarily within limbic regions of the brain. {ECO:0000269|PubMed:1834671}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2227840 rs6282 rs2227849 rs2227845 rs2227843 rs2227852 rs538877978 rs2227850 rs2227851 rs1800762 rs1577263526 rs776114395 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | HPG |
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