| Gene Information | |
|---|---|
| Gene Name | NEK8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 979 |
| Protein Names | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000160602 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q8TD19 |
| Gene Card | NEK9 |
| Uniprot ID | Q8TD19 |
| Pfam | PF00069; PF00415 |
| In ASD | no |
| Allosteric Prediction | no (-1.000038758) |
| Ortholog in Animals | Alpaca_ NEK8 ( ortholog_one2one ) Dog_ NEK8 ( ortholog_one2one ) GuineaPig_ NEK8 ( ortholog_one2one ) Macaque_ NEK8 ( ortholog_one2one ) Mouse_ Nek8 ( ortholog_one2one ) Pig_ NEK8 ( ortholog_one2one ) Rat_ Nek8 ( ortholog_one2one ) Rabbit_ NEK8 ( ortholog_one2one ) |
| Ohnologs | NEK9 |
| Paralogs | NEK5, NEK11, NEK2, NEK7, NEK9, NEK3, NEK6, NEK10 |
| Tissue | NA |
| Tissue Specificity | Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.157143(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3ZKE (X-ray 2.20A ) 3ZKF (X-ray 2.60A ) |
| DBSNP | rs879253775 rs10146482 rs1555352529 rs142859694 rs36014869 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14660563}. Nucleus {ECO:0000269|PubMed:14660563}. |
| Mouse PG classification | HPG |
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