| Gene Information | |
|---|---|
| Gene Name | MEIS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 390 |
| Protein Names | Homeobox protein Meis1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000143995 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O00470 |
| Gene Card | MEIS1 |
| Uniprot ID | O00470 |
| Pfam | PF05920; PF16493 |
| In ASD | no |
| Allosteric Prediction | no (-0.389152881) |
| Ortholog in Animals | Alpaca_ MEIS1 ( ortholog_one2one ) Dog_ MEIS1 ( ortholog_one2one ) GuineaPig_ MEIS1 ( ortholog_one2one ) Macaque_ MEIS1 ( ortholog_one2one ) Mouse_ Meis1 ( ortholog_one2one ) Pig_ MEIS1 ( ortholog_one2one ) Rat_ Meis1 ( ortholog_one2one ) Rabbit_ MEIS1 ( ortholog_one2one ) |
| Ohnologs | MEIS3, MEIS2 |
| Paralogs | PKNOX2, PBX4, PBX3, PBX1, TGIF2LX, TGIF2LY, PKNOX1, MEIS2, TGIF2, PBX2, MEIS3, TGIF1 |
| Tissue | NA |
| Tissue Specificity | Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4XRS (X-ray 3.50A ) 5EGO (X-ray 2.54A ) |
| DBSNP | rs61752693 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. |
| Mouse PG classification | NA |
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