| Gene Information | |
|---|---|
| Gene Name | DRD4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 419 |
| Protein Names | D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor) |
| Target Name | dopamine d4 receptor |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000069696 ) 3 ( ENSG00000276825 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P21917 |
| Gene Card | DRD4 |
| Uniprot ID | P21917 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.44200143) |
| Ortholog in Animals | Alpaca_ DRD4 ( ortholog_one2one ) Dog_ DRD4 ( ortholog_one2one ) Macaque_ DRD4 ( ortholog_one2one ) Mouse_ Drd4 ( ortholog_one2one ) Pig_ DRD4 ( ortholog_one2one ) Rat_ Drd4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HRH2, TAAR6, HRH1, DRD1, GPR52, HTR1A, HTR1D, CHRM3, CHRM4, HRH3, TAAR5, HTR4, TAAR1, GPR21, CHRM1, HRH4, TAAR9, CHRM5, TAAR8, DRD3, GPR84, CHRM2, GPR161, DRD5, TAAR2 |
| Tissue | pineal.gland |
| Tissue Specificity | Highly expressed in retina. Detected at much lower levels in brain, in amygdala, thalamus, hypothalamus, cerebellum and pituitary. {ECO:0000269|PubMed:7769992}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5WIU (X-ray 1.96A ) 5WIV (X-ray 2.14A ) |
| DBSNP | rs1800443 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:1319557, ECO:0000269|PubMed:16423344, ECO:0000269|PubMed:1840645, ECO:0000269|PubMed:20100572, ECO:0000269|PubMed:27659709, ECO:0000269|PubMed:29051383, ECO:0000269|PubMed:7512953, ECO:0000269|PubMed:7643093, ECO:0000269|PubMed:8078498, ECO:0000269|PubMed:9003072}; Multi-pass membrane protein {ECO:0000269|PubMed:20100572, ECO:0000269|PubMed:29051383}. |
| Mouse PG classification | HPG |
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