| Gene Information | |
|---|---|
| Gene Name | DRD3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 400 |
| Protein Names | D(3) dopamine receptor (Dopamine D3 receptor) |
| Target Name | dopamine d3 receptor |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000151577 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P35462 |
| Gene Card | DRD3 |
| Uniprot ID | P35462 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.747974571) |
| Ortholog in Animals | Alpaca_ DRD3 ( ortholog_one2one ) Dog_ DRD3 ( ortholog_one2one ) GuineaPig_ DRD3 ( ortholog_one2one ) Macaque_ DRD3 ( ortholog_one2one ) Mouse_ Drd3 ( ortholog_one2one ) Pig_ DRD3 ( ortholog_one2one ) Rat_ Drd3 ( ortholog_one2one ) Rabbit_ DRD3 ( ortholog_one2one ) |
| Ohnologs | DRD2, HTR1E |
| Paralogs | HRH2, TAAR6, DRD4, HRH1, DRD1, GPR52, HTR1A, HTR1D, CHRM3, CHRM4, HRH3, TAAR5, HTR4, TAAR1, GPR21, CHRM1, HRH4, TAAR9, CHRM5, TAAR8, GPR84, CHRM2, GPR161, DRD5, TAAR2 |
| Tissue | NA |
| Tissue Specificity | Brain. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 3PBL (X-ray 2.89A ) 7CMU (EM 3.00A ) 7CMV (EM 2.70A ) |
| DBSNP | rs6280 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19520868}; Multi-pass membrane protein {ECO:0000269|PubMed:19520868}. Note=Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells. |
| Mouse PG classification | NA |
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