| Gene Information | |
|---|---|
| Gene Name | IRS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1242 |
| Protein Names | Insulin receptor substrate 1 (IRS-1) |
| Target Name | insulin receptor substrate 1 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000169047 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P35568 |
| Gene Card | IRS1 |
| Uniprot ID | P35568 |
| Pfam | PF02174; PF00169 |
| In ASD | no |
| Allosteric Prediction | yes (1.712080842) |
| Ortholog in Animals | Alpaca_ IRS1 ( ortholog_one2one ) Dog_ IRS1 ( ortholog_one2one ) GuineaPig_ IRS1 ( ortholog_one2one ) Macaque_ IRS1 ( ortholog_one2one ) Mouse_ Irs1 ( ortholog_one2one ) Pig_ IRS1 ( ortholog_one2one ) Rat_ Irs1 ( ortholog_one2one ) Rabbit_ IRS1 ( ortholog_one2one ) |
| Ohnologs | IRS2 |
| Paralogs | IRS2, IRS4 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001916(Rat);0.016393(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1IRS (NMR - ) 1K3A (X-ray 2.10A ) 1QQG (X-ray 2.30A ) 2Z8C (X-ray 3.25A ) 5U1M (X-ray 1.80A ) 6BNT (X-ray 3.20A ) 7PPL (X-ray 1.53A ) 7PPM (X-ray 1.48A ) |
| DBSNP | rs1801108 rs1801118 rs1801276 rs104893642 rs1259467443 rs1801120 rs1801277 rs1801278 rs3731594 |
| Subcellular location [CC] | NA |
| Mouse PG classification | HPG |
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