| Gene Information | |
|---|---|
| Gene Name | DRD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 446 |
| Protein Names | D(1A) dopamine receptor (Dopamine D1 receptor) |
| Target Name | dopamine d1 receptor |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000184845 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P21728 |
| Gene Card | DRD1 |
| Uniprot ID | P21728 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.642623137) |
| Ortholog in Animals | Alpaca_ DRD1 ( ortholog_one2one ) Dog_ DRD1 ( ortholog_one2one ) GuineaPig_ DRD1 ( ortholog_one2one ) Macaque_ DRD1 ( ortholog_one2one ) Mouse_ Drd1 ( ortholog_one2one ) Pig_ DRD1 ( ortholog_one2one ) Rat_ Drd1 ( ortholog_one2one ) Rabbit_ DRD1 ( ortholog_one2one ) |
| Ohnologs | ADRA1A, ADRA1D, DRD5 |
| Paralogs | HRH2, TAAR6, DRD4, HRH1, GPR52, HTR1A, HTR1D, CHRM3, CHRM4, HRH3, TAAR5, HTR4, TAAR1, GPR21, CHRM1, HRH4, TAAR9, CHRM5, TAAR8, DRD3, GPR84, CHRM2, GPR161, DRD5, TAAR2 |
| Tissue | caudate.nucleus, diencephalon, putamen, nucleus.accumbens |
| Tissue Specificity | Detected in caudate, nucleus accumbens and in the olfactory tubercle. {ECO:0000269|PubMed:2144334}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7CKW (EM 3.22A ) 7CKX (EM 3.54A ) 7CKY (EM 3.20A ) 7CKZ (EM 3.10A ) 7CRH (EM 3.30A ) 7F0T (EM 3.10A ) 7F1O (EM 3.13A ) 7F1Z (EM 3.46A ) 7F23 (EM 3.58A ) 7F24 (EM 4.16A ) 7JOZ (X-ray 3.80A ) 7JV5 (EM 3.00A ) 7JVP (EM 2.90A ) 7JVQ (EM 3.00A ) 7LJC (EM 3.00A ) 7LJD (EM 3.20A ) 7X2C (EM 3.20A ) 7X2D (EM 3.30A ) 7X2F (EM 3.00A ) |
| DBSNP | rs5327 rs879844008 rs5330 rs5331 rs74414188 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P18901}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18901}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P18901}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18901}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q61616}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q61616}. Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. {ECO:0000250|UniProtKB:P18901}. |
| Mouse PG classification | NA |
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