| Gene Information | |
|---|---|
| Gene Name | AXL |
| Organism | Homo sapiens (Human) |
| Gene Length | 894 |
| Protein Names | Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) |
| Target Name | tyrosine-protein kinase ufo |
| Target Type | Successful target |
| Gene Age | 987 ( ENSG00000167601 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P30530 |
| Gene Card | AXL |
| Uniprot ID | P30530 |
| Pfam | PF00041; PF07714 |
| In ASD | no |
| Allosteric Prediction | yes (0.613944707) |
| Ortholog in Animals | Alpaca_ AXL ( ortholog_one2one ) Dog_ AXL ( ortholog_one2one ) GuineaPig_ AXL ( ortholog_one2one ) Macaque_ AXL ( ortholog_one2one ) Mouse_ Axl ( ortholog_one2one ) Pig_ AXL ( ortholog_one2one ) Rat_ Axl ( ortholog_one2one ) Rabbit_ AXL ( ortholog_one2one ) |
| Ohnologs | TYRO3, MERTK |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue. {ECO:0000269|PubMed:7896447}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001823(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2C5D (X-ray 3.30A ) 4RA0 (X-ray 3.07A ) 5U6B (X-ray 2.84A ) 5VXZ (X-ray 2.30A ) |
| DBSNP | rs35202236 rs7249222 rs751738506 rs747576071 rs1240393707 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:28076778, ECO:0000269|PubMed:29379210, ECO:0000269|PubMed:7896447}; Single-pass type I membrane protein {ECO:0000269|PubMed:7896447}. |
| Mouse PG classification | NA |
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