| Gene Information | |
|---|---|
| Gene Name | ALCAM |
| Organism | Homo sapiens (Human) |
| Gene Length | 583 |
| Protein Names | CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000170017 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13740 |
| Gene Card | ALCAM |
| Uniprot ID | Q13740 |
| Pfam | PF08205 |
| In ASD | no |
| Allosteric Prediction | no (-0.370037906) |
| Ortholog in Animals | Alpaca_ ALCAM ( ortholog_one2one ) Dog_ ALCAM ( ortholog_one2one ) GuineaPig_ ALCAM ( ortholog_one2one ) Macaque_ ALCAM ( ortholog_one2one ) Mouse_ Alcam ( ortholog_one2one ) Pig_ ALCAM ( ortholog_one2one ) Rat_ Alcam ( ortholog_one2one ) Rabbit_ ALCAM ( ortholog_one2one ) |
| Ohnologs | MCAM, BCAM |
| Paralogs | AGER, MCAM, BCAM |
| Tissue | NA |
| Tissue Specificity | Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:15048703). Detected on monocyte-derived dendritic cells (at protein level) (PubMed:16352806). Detected at low levels in spleen, placenta, liver (PubMed:9502422). Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7760007). Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415). Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:9502422). {ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:24740813, ECO:0000269|PubMed:7760007, ECO:0000269|PubMed:9502422}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5A2F (X-ray 1.86A ) |
| DBSNP | rs10933819 rs1044240 rs1044243 rs12629872 rs2291375 rs34926152 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:23169771, ECO:0000269|PubMed:24740813, ECO:0000269|PubMed:24945728, ECO:0000269|PubMed:7760007}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q61490}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q61490}. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse (PubMed:15294938). {ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806}.; [Isoform 3]: Secreted {ECO:0000269|PubMed:15496415}. |
| Mouse PG classification | NA |
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