Gene Information
Gene NamePLSCR3
OrganismHomo sapiens (Human)
Gene Length295
Protein NamesPhospholipid scramblase 3 (PL scramblase 3) (Ca(2+)-dependent phospholipid scramblase 3)
Target NameNA
Target TypeNA
Gene Age680 ( ENSG00000187838 )
3 ( ENSG00000284009 )
Evolutionary StageMammalia
AlphaFoldDBQ9NRY6
Gene CardPLSCR3
Uniprot IDQ9NRY6
PfamPF03803
In ASDno
Allosteric Predictionno (-0.216914602)
Ortholog in AnimalsAlpaca_ PLSCR3 ( ortholog_one2one )
Dog_ PLSCR3 ( ortholog_one2one )
GuineaPig_ PLSCR3 ( ortholog_one2one )
Macaque_ PLSCR3 ( ortholog_one2one )
Mouse_ Plscr3 ( ortholog_one2one )
Pig_ PLSCR3 ( ortholog_one2one )
Rat_ Plscr3 ( ortholog_one2one )
Rabbit_ PLSCR3 ( ortholog_one2one )
OhnologsPLSCR4, PLSCR2, PLSCR1
ParalogsPLSCR4, PLSCR1, PLSCR5, PLSCR2
TissueNA
Tissue SpecificityExpressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs3744549 
Subcellular location [CC]Mitochondrion membrane {ECO:0000269|PubMed:14573790, ECO:0000269|PubMed:17226776, ECO:0000269|PubMed:18491232};
Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q6QBQ4}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q6QBQ4};
Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q6QBQ4}. Nucleus {ECO:0000250|UniProtKB:Q9JIZ9}. Note=Palmitoylation regulates its localization to the cell membrane or the nucleus;
trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus. {ECO:0000250|UniProtKB:Q9JIZ9}.
Mouse PG classificationNA
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