| Gene Information | |
|---|---|
| Gene Name | DPYD |
| Organism | Homo sapiens (Human) |
| Gene Length | 1025 |
| Protein Names | Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) |
| Target Name | dihydrothymine dehydrogenase |
| Target Type | Successful target |
| Gene Age | >4290 ( ENSG00000188641 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q12882 |
| Gene Card | DPYD |
| Uniprot ID | Q12882 |
| Pfam | PF01180; PF14691; PF07992 |
| In ASD | no |
| Allosteric Prediction | yes (0.936870291) |
| Ortholog in Animals | Alpaca_ DPYD ( ortholog_one2one ) Dog_ DPYD ( ortholog_one2one ) GuineaPig_ DPYD ( ortholog_one2one ) Macaque_ DPYD ( ortholog_one2one ) Mouse_ Dpyd ( ortholog_one2one ) Pig_ DPYD ( ortholog_one2one ) Rat_ Dpyd ( ortholog_one2one ) Rabbit_ DPYD ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FDXR, DHODH |
| Tissue | NA |
| Tissue Specificity | Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1801265 rs2297595 rs1801266 rs1801158 rs1801159 rs1801160 rs1801267 rs1801268 |
| Subcellular location [CC] | Cytoplasm. |
| Mouse PG classification | NA |
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