| Gene Information | |
|---|---|
| Gene Name | GRIA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 883 |
| Protein Names | Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (GluA2) |
| Target Name | glutamate receptor 2 |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000120251 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P42262 |
| Gene Card | GRIA2 |
| Uniprot ID | P42262 |
| Pfam | PF01094; PF00060; PF10613 |
| In ASD | yes |
| Allosteric Prediction | yes (1.601221943) |
| Ortholog in Animals | Alpaca_ GRIA2 ( ortholog_one2one ) Dog_ GRIA2 ( ortholog_one2one ) GuineaPig_ GRIA2 ( ortholog_one2one ) Macaque_ GRIA2 ( ortholog_one2one ) Mouse_ Gria2 ( ortholog_one2one ) Pig_ GRIA2 ( ortholog_one2one ) Rat_ Gria2 ( ortholog_one2one ) Rabbit_ GRIA2 ( ortholog_one2one ) |
| Ohnologs | GRIA3, GRIA4, GRIA1 |
| Paralogs | GRIN3A, GRIN2A, GRIK5, GRIN2C, GRID1, GRID2, GRIK3, GRIN2D, GRIN1, GRIK4, GRIA3, GRIK1, GRIA1, GRIN3B, GRIK2, GRIA4, GRIN2B |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.357195(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2WJW (X-ray 1.80A ) 2WJX (X-ray 4.10A ) 2XHD (X-ray 1.80A ) 3R7X (X-ray 2.10A ) 3RN8 (X-ray 1.70A ) 3RNN (X-ray 1.75A ) 3UA8 (X-ray 1.90A ) 5H8S (X-ray 1.70A ) 5YBF (X-ray 1.50A ) 5YBG (X-ray 1.52A ) 5ZG0 (X-ray 1.58A ) 5ZG1 (X-ray 1.32A ) 5ZG2 (X-ray 1.25A ) 5ZG3 (X-ray 1.65A ) 7F3O (X-ray 1.44A ) |
| DBSNP | rs1735116193 rs1735294501 rs17850674 rs17850675 rs1735303754 rs1553956958 rs1579377564 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:23739980, ECO:0000269|PubMed:31300657}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P23819}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23819}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (By similarity). Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P23819}. |
| Mouse PG classification | NA |
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