| Gene Information | |
|---|---|
| Gene Name | DPP9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 863 |
| Protein Names | Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9) |
| Target Name | dipeptidyl peptidase 9 |
| Target Type | Clinical trial target |
| Gene Age | >4290 ( ENSG00000142002 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q86TI2 |
| Gene Card | DPP9 |
| Uniprot ID | Q86TI2 |
| Pfam | PF19520; PF00930; PF00326 |
| In ASD | yes |
| Allosteric Prediction | yes (0.710600018) |
| Ortholog in Animals | Alpaca_ DPP9 ( ortholog_one2one ) Dog_ DPP9 ( ortholog_one2one ) GuineaPig_ DPP9 ( ortholog_one2one ) Macaque_ DPP9 ( ortholog_one2one ) Mouse_ Dpp9 ( ortholog_one2one ) Pig_ DPP9 ( ortholog_one2one ) Rat_ Dpp9 ( ortholog_one2one ) |
| Ohnologs | DPP8 |
| Paralogs | APEH, FAP, DPP8, DPP6, DPP4, DPP10 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in brain. {ECO:0000269|PubMed:12459266, ECO:0000269|PubMed:12662155, ECO:0000269|PubMed:15245913}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6EOQ (X-ray 3.00A ) 6EOR (X-ray 2.90A ) 6QZV (X-ray 3.00A ) 6X6A (EM 3.60A ) 6X6C (EM 2.90A ) 7A3F (X-ray 2.90A ) 7JKQ (EM 3.30A ) 7JN7 (EM 3.30A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm, cytosol {ECO:0000269|PubMed:12662155, ECO:0000269|PubMed:15245913}.; [Isoform 2]: Nucleus {ECO:0000269|PubMed:24562348}. |
| Mouse PG classification | NA |
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