| Gene Information | |
|---|---|
| Gene Name | DPP8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 898 |
| Protein Names | Dipeptidyl peptidase 8 (DP8) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 1) (DPRP-1) (Dipeptidyl peptidase VIII) (DPP VIII) (Prolyl dipeptidase DPP8) |
| Target Name | dipeptidyl peptidase 8 |
| Target Type | Clinical trial target |
| Gene Age | >4290 ( ENSG00000074603 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q6V1X1 |
| Gene Card | DPP8 |
| Uniprot ID | Q6V1X1 |
| Pfam | PF19520; PF00930; PF00326 |
| In ASD | yes |
| Allosteric Prediction | yes (0.566392375) |
| Ortholog in Animals | Alpaca_ DPP8 ( ortholog_one2one ) Dog_ DPP8 ( ortholog_one2one ) GuineaPig_ DPP8 ( ortholog_one2one ) Macaque_ DPP8 ( ortholog_one2one ) Mouse_ Dpp8 ( ortholog_one2one ) Pig_ DPP8 ( ortholog_one2one ) Rat_ Dpp8 ( ortholog_one2one ) Rabbit_ DPP8 ( ortholog_one2one ) |
| Ohnologs | DPP9 |
| Paralogs | APEH, FAP, DPP6, DPP9, DPP4, DPP10 |
| Tissue | testis |
| Tissue Specificity | Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain. {ECO:0000269|PubMed:11012666, ECO:0000269|PubMed:12662155}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6EOO (X-ray 2.50A ) 6EOP (X-ray 2.40A ) 6EOS (X-ray 3.10A ) 6EOT (X-ray 3.50A ) 6HP8 (X-ray 2.50A ) 6QZW (X-ray 3.20A ) 6TRW (X-ray 3.00A ) 6TRX (X-ray 3.20A ) 7A3G (X-ray 2.80A ) 7A3I (X-ray 2.80A ) 7A3J (X-ray 3.00A ) 7A3K (X-ray 2.65A ) 7A3L (X-ray 2.80A ) 7AYQ (X-ray 2.45A ) 7AYR (X-ray 2.69A ) 7OR4 (X-ray 2.44A ) 7OZ7 (X-ray 2.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11012666, ECO:0000269|PubMed:12534281, ECO:0000269|PubMed:12662155}. |
| Mouse PG classification | NA |
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